Quality and Reliability

Quality matters – B·R·A·H·M·S PCT assays

BRAHMS-PCT-qualityIt has come to our attention that Beckman Coulter is distributing marketing material using our trademark B·R·A·H·M·S PCT. We therefore wish to clarify that Beckman Coulter’s Access PCT assay is none of the licensed B·R·A·H·M·S PCT assays. Beckman Coulter is not a licensee of B·R·A·H·M·S and is not allowed to use trademarks or other intellectual property rights owned by B·R·A·H·M·S. In addition to that, Beckman Coulter’s Access PCT assay does not make use of the validated B·R·A·H·M·S antibodies.

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B·R·A·H·M·S immunoassays are completely free of biotin

Biotin contained in patients’ blood may interfere with lab tests that utilize the binding of biotin and streptavidin in their assay design. In these assays interference with biotin can lead to false high or false low values depending on the design of the lab tests.Ref-1-2 Incorrect test results may ultimately lead to misdiagnosis and inappropriate patient management.Ref-3

  • B·R·A·H·M·S KRYPTOR assays are free of biotin since their unique homogenous design does not require the biotin/streptavidin interaction.
  • B·R·A·H·M·S manual RIA and LIA assays do not include biotin in their proven coated tube design.


Read more about the outstanding precision of the B·R·A·H·M·S KRYPTOR analyzer family >

You have questions? Please contact our customer service.

Read more about biotin-free prenatal screening assays >


The gold standard in prenatal screening: Complete B·R·A·H·M·S biomarker assay portfolio

B·R·A·H·M·S is the only provider of a complete prenatal screening biomarker portfolio, offering all 8 biomarker assays to measure AFP, Free ß hCG, hCG + ß, Inhibin A, PAPP-A, PlGF, sFlt-1 and uE3 on a fully automated immunoanalyser in a very precise, fast and easy way. B·R·A·H·M·S prenatal screening solutions cover first trimester trisomy and pre-eclampsia screening, second trimester trisomy and neural tube defect screening as well as an improved diagnosis and prognosis of pre-eclampsia after 20 weeks of gestation.

Read more: Complete portfolio of prenatal screening assays >

B·R·A·H·M·S KRYPTOR GOLD and B·R·A·H·M·S KRYPTOR prenatal screening assays are fulfilling the requirements established by Fetal Medicine Foundation (FMF) for the biochemical screening for chromosomal abnormalities and pre-eclampsia.
Download Fetal Medicine Foundation Certificate >



Ref-1: Piketty ML, Polak M et al. (2017). Clin Chem Lab Med 55(6): 780-788.

Ref-2: Trambas C, Lu Z, et al. (2018). Ann Clin Biochem 55(2):205-215.

Ref-3: Elston MS, Sehgal S et al. J Clin Endocrinol Metab 2016; 101(9): 3251-3255.

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