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New diagnostic possibilities with B·R·A·H·M·S Copeptin proAVP KRYPTOR

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Arginine-stimulated copeptin measurements in the differential diagnosis of diabetes insipidus: a prospective diagnostic study

Autoren: Winzeler B, Cesana-Nigro N, Refardt J, Vogt D, Imber C, Morin B, Popovic M, Steinmetz M, Sailer C, Szinnai G, Chifu I, Fassnacht M, Christ-Crain M
Source: https://doi.org/10.1016/S0140-6736(19)31255-3
Indication: Electrolyte Disorders
Product: Copeptin

Differential diagnosis of diabetes insipidus is challenging. The most reliable approach is hypertonic saline-stimulated copeptin measurements.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31255-3/fulltext >

EJE AWARD 2019: New diagnostic approaches for patients with polyuria polydipsia syndrome

Autoren: Christ-Crain, M
Source: https://doi.org/10.1530/EJE-19-0163
Indication: Electrolyte Disorders
Access: Open Access
Product: Copeptin

Diabetes insipidus (DI), be it from central or nephrogenic origin, must be differentiated from secondary forms of hypotonic polyuria such as primary polydipsia. Differentiation is crucial since wrong treatment can have deleterious consequences.
https://eje.bioscientifica.com/view/journals/eje/181/1/EJE-19-0163.xml >

Copeptin role in polyuria-polydipsia syndrome (PPS) differential diagnosis and reference range in paediatric age

Autoren: Tuli G, Tessaris D, Einaudi S, Matarazzo P and de Sanctis L
Source: Clin Endocrinol (Oxf). 2018 Jun;88(6):873-879.
Indication: Electrolyte Disorders
Product: Copeptin

Copeptin evaluation holds promises as a diagnostic tool in paediatric PPS; its interpretation might be useful to promptly distinguish NDI, even avoiding the WDT need.
https://www.ncbi.nlm.nih.gov/pubmed/29464737 >

A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus

Autoren: Wiebke Fenske, M.D., Ph.D., Julie Refardt, M.D., Irina Chifu, M.D., Ingeborg Schnyder, M.D., Bettina Winzeler, M.D., Juliana Drummond, M.D., Antônio Ribeiro-Oliveira, Jr., M.D., Ph.D., Tilman Drescher, M.D., Stefan Bilz, M.D., Deborah R. Vogt, Ph.D., Uwe Malzahn, Ph.D., Matthias Kroiss, M.D., Ph.D., Emanuel Christ, M.D., Ph.D., Christoph Henzen, M.D., Stefan Fischli, M.D., Anke Tönjes, M.D., Beat Mueller, M.D., Jochen Schopohl, M.D., Jörg Flitsch, M.D., Georg Brabant, M.D., Martin Fassnacht, M.D., and Mirjam Christ-Crain, M.D., Ph.D.
Source: N Engl J Med 2018; 379:428-439 DOI: 10.1056/NEJMoa1803760
Indication: Electrolyte Disorders
Product: Copeptin

The direct measurement of hypertonic saline–stimulated plasma copeptin had greater diagnostic accuracy than the water-deprivation test in patients with hypotonic polyuria.
https://www.nejm.org/doi/full/10.1056/NEJMoa1803760

Copeptin levels and commonly used laboratory parameters in hospitalised patients with severe hypernatraemia - the "Co-MED study"

Autoren: Nigro N, Winzeler B, Suter-Widmer I, Schuetz P, Arici B, Bally M, Refardt J, Betz M, Gashi G, Urwyler SA, Burget L, Blum CA, Bock A, Huber A, Muller B and Christ-Crain M
Source: Crit Care 2018;22 (1),Feb 9: 33.
Indication: Electrolyte Disorders
Access: Open Access
Product: Copeptin

Copeptin and urea reliably identify patients with CDI and are therefore helpful tools for therapeutic management in patients with severe hypernatraemia.
https://www.ncbi.nlm.nih.gov/pubmed/29422070 >

  1. Primary polydipsia in the medical and psychiatric patient: characteristics, complications and therapy
  2. Effects of hydration on plasma copeptin, glycemia and gluco-regulatory hormones: a water intervention in humans
  3. Release and Decay Kinetics of Copeptin vs AVP in Response to Osmotic Alterations in Healthy Volunteers
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