Copeptin, a 39-amino acid glycopeptide, is the C-terminal part of the prohormone of arginine vasopressin (AVP) or antidiuretic hormone (ADH).

The pre-pro-vasopressin precursor is synthesized and processed into its three components – AVP, Neurophysin II and Copeptin – within the hypothalamus; afterwards these products are transported along the neuronal axons in the granules of the posterior hypophysis (pituitary gland), where they are stored and released under appropriate stimulus.

AVP and Copeptin release >

copeptin keyvisual ami electrolyte disorders

Copeptin – the stable surrogate marker of vasopressin

Copeptin is released together with AVP in equimolar amounts but while the measurement of the unstable AVP is prone to pre-analytical errors, Copeptin constitutes a stable surrogate marker for this key hormone in the human body.

The extraordinary stability of Copeptin eases lab logistics: The Thermo Scientific B·R·A·H·M·S Copeptin proAVP KRYPTOR assay reliably replaces the measurement of vasopressin and opens the possibility to achieve the full diagnostic potential of this hormone in rule-out of myocardial infarction (AMI) and water-balance disorders.

Advantages of Copeptin measurement >

Discover the clinical use of Copeptin

Early rule-out of Acute Myocardial Infarction (AMI)

Safe and early rule-out of chest pain patients with suspected AMI using Copeptin in combination with Troponin

Diabetes insipidus after neurosurgery

Early goal directed management of patients undergoing pituitary surgery with Copeptin

Polyuria-polydipsia syndrome

Differential diagnosis of central diabetes insipidus from nephrogenic diabetes insipidus with Copeptin