Copeptin: Overcome the Limitation of Vasopressin (AVP/ADH) Measurement
Arginine vasopressin (AVP), also called antidiuretic hormone (ADH) is one of the key hormones in the human body. AVP has important physiological functions, including vascular tonus, the homeostasis of fluid balance and regulation of the endocrine stress response.Ref-1 But due to technical limitations of vasopressin assays, vasopressin concentrations were rarely measured in the past.
"Quantification of AVP can be difficult, but copeptin is stable in plasma and can be easily measured with a sandwich immunoassay. For this reason, copeptin has emerged as a promising marker for the diagnosis of AVP-dependent fluid disorders."
Christ-Crain and Fenske. Nature Reviews Endocrinology 2016
The direct measurement of hypertonic saline–stimulated plasma copeptin had greater diagnostic accuracy than the water-deprivation test in patients with hypotonic polyuria.
Fenske W, N Engl J Med (2018)
Advantages of Copeptin measurement
Extremely high stability ex vivo
Ex vivo Copeptin stability (<20% loss of analyte) has been shown even for at least 7 days at room temperature. Ref-2
Not significantly bound to platelets
Results you can trust; AVP in contrast is bound to platelets leading to falsely elevated or varying measurements of free plasma AVP. Ref-2
Easy to measure
Sensitive Automated sandwich-immunoassay
B·R·A·H·M·S Copeptin proAVP KRYPTOR is available on KRYPTOR Compact PLUS, a fully automated bench-top analyzer with easy and continuous sample loading backed by the Nobel Prize-winning TRACE technology.
Correlates better with serum osmolality than Vasopressin itself
Copeptin helps to better evaluate response to osmotic and haemodynamic changes. Ref-3
Reduced physical and psychological stress for patients
The ease and speed of B·R·A·H·M·S Copeptin proAVP KRYPTOR assay improves the diagnosis of AVP-dependent fluid disorders, for a better patients care. Ref-4, Ref-5, Ref-6
Fast turnaround time
Results are available in less than 30 minutes.
Ref-1: Morgenthaler et al. Copeptin – Biochemistry and Clinical Diagnostics, UNI-MED – 2015
Ref-2: Morgenthaler et al. Clin Chem 2006
Ref-3: Balanescu et al. JCEM 2011
Ref-4: Fenske et al. JCEM 2011
Ref-5: Timper et al. JCEM 2015