New diagnostic possibilities with B·R·A·H·M·S Copeptin proAVP KRYPTOR
Learn morePlasma copeptin levels predict disease progression and tolvaptan efficacy in autosomal dominant polycystic kidney disease
- Autoren: Gansevoort R, van Gastel M, Chapman A, Blais J, Czerwiec F, Higashihara E, Lee J, Ouyang J, Perrone R, Stade K, Torres V, and Devuyst O
- Source: https://doi.org/10.1016/j.kint.2018.11.044
- Indication: Nephrology
- Product: Copeptin
In the TEMPO 3:4 Trial, treatment with tolvaptan, a vasopressin V2 receptor antagonist, slowed the increase in total kidney volume and decline in estimated glomerular filtration rate (eGFR) in autosomal dominant polycystic kidney disease (ADPKD).
https://www.kidney-international.org/article/S0085-2538(19)30041-9/abstract >
Is serum copeptin a modifiable biomarker in autosomal dominant polycystic kidney disease?
- Autoren: Tasneem M, Mannix C, Wong A, Zhang J and Rangan G
- Source: World J Nephrol 2018;7 (2),Mar 6: 51-57
- Indication: Nephrology
- Access: Open Access
- Product: Copeptin
Copeptin (the C-terminal glycoprotein of the precursor AVP peptide) is an accurate surrogate marker of AVP release that is stable and easily measured by immunoassay. Cohort studies show that serum copeptin is correlated with disease severity in ADPKD, and predicts future renal events [decline in renal function and increase in total kidney volume (TKV)].
https://www.ncbi.nlm.nih.gov/pubmed/29527508 >
Effect of Coaching to Increase Water Intake on Kidney Function Decline in Adults With Chronic Kidney Disease: The CKD WIT Randomized Clinical Trial
- Autoren: Clark WF, Sontrop JM, Huang SH, Gallo K, Moist L, House AA, Cuerden MS, Weir MA, Bagga A, Brimble S, Burke A, Muirhead N, Pandeya S and Garg AX
- Source: JAMA 2018;319 (18),May 8: 1870-1879.
- Indication: Nephrology
- Product: Copeptin
Among adults with chronic kidney disease, coaching to increase water intake compared with coaching to maintain the same water intake did not significantly slow the decline in kidney function after 1 year. However, the study may have been underpowered to detect a clinically important difference.
https://www.ncbi.nlm.nih.gov/pubmed/29801012 >